Mission 2- You start this mission in a cave. Run forward and smash the doorway in front of you to enter the next room. In here, follow the path until you see another doorway to smash through, and collect the red orbs inside. There should be two more doorways inside here, smash the last one to cause the wall beside you to shift. Pull out Ebony & Ivory, and begin shooting the Flambats that come out. There's a door where the bats came out, but before you go through it, smash another door on the far side to make the wall move again. Run over here, and you should fall through the floor onto a hefty amount of red orbs. Now go through the door, and you'll be in a square room with square tiles on the floor. Go up to the door in front of you to activate the puzzle. The middle square will light up, and when you step on it, four white orbs will pop out of the ground for a limited amount of time. You have to try to smash them, it takes about 4-5 slashes with the Rebellion to do the trick. If you can destroy all 4 in one turn, or 3 in a row three times, the door will open. In this new area, follow the path, and smash any doorways that you come up to. one of them should make the wall move, and you need to follow the new path. smash another statue to make the wall move again. Flambats will come out, so start shooting, or just avoid them and look for the next doorway. The wall behind you should move, so turn around and smash the doorway in this new room. Go down the path behind the doorway, and slash the blue statue until it is completely lit up. This will cause the door at the very end of the path to open up. Before you leave the passage way with the blue sphere, examine the coffin leaning against the wall to find another secret room. Go through the door at the end of the hall, and you'll find yourself in a new room, surrounded by enemies. After you kill all the enemies, 2 Goatlings will attack you. One will fight you from the ground, and one will fight you from the air. Kill the one in the air first to make things easier. After they are dead, you will be able to gain the Aerial Heart. Recharge at the DT charger in the corner if you need to, and use the new heart to fly out of the room and end the mission.

Mission 3- Follow the path until it splits into 2 directions. Keep going in the direction that you were going in until you can turn to your right. At this turn, you should find a blue orb fragment in the far left corner. Turn around and head back down the path. A Goatling will start attacking you by making energy shoot up from the ground. Just keep dodging until you get right up under him, then jump up and bring him down with a downward swipe. After you kill him and the rest of the enemies, turn around and go into one of the red doors on the right wall. This will start another secret mission. After you finish with it, go through the big door on the left side of the screen. It's time for your first boss fight against Orangguerra. Refer to the boss guide for tips on how to kill him. After you kill him, you will receive a key to be used in the hallway outside. Exit the room and look for a door with 2 red orbs next to it, go through this door to end the mission.

Mission 4- Follow the path you are on, and jump up on the ledges around you to get some red orbs. Further down the path, you will be attacked by some enemies. Kill them, and check the ledges for more orbs. Knock down the door at the end of the path, and follow the new path until you reach the door at the end. While you are exploring, take note of the gate on the right side of the screen blocking your progress; you'll need to return here later. In this new room, you must kill all of the enemies, and then enter the door at the top of the stairs. In this room, you will receive the Quick Heart. Before you leave, jump up on top of the machinery, and then up to the ceiling to receive a yellow orb. Go back outside, and look for a triangular statue with a sphere on top. Equip the Quick Heart, DT, and hit the statue to make the gate blocking your way go up. Run to the gate, and press Circle to roll under it just in time. If you don't make it, go back and try again. Explore the new area, and look for a garage like door, go through here to start another secret mission. Now go through the main door, and prepare for a boss fight with Jokatguin. After the boss is dead, a door to your right should open up. Go through here to receive the shotgun, and to end the mission.

Mission 5- Walk towards the red orb, and a force field should go up in front of you. You will have to kill Friki & Geri before you will be allowed to leave. After they are dead, walk out on to the street and you will be attacked by two or three Blood Goats. After you defeat them, explore the area behind where you entered to find a few red orbs, leave the area after you are done exploring. On the next street, you will have to fight Orangguerra again, but he's allot easier this time. Go through one of the doors in this area to reach a secret room. Continue down the street until you reach a truck blocking your path. You'll have to jump over it. After you do, you'll be attacked by 3 infested tanks. After you kill them, follow the highway up to reach a red orb and a blue orb. Jump down here, and you should be in an area surrounded by fire. Explore until you find a ledge that you can use to jump over the far wall. Go through the opening in the chain link fence, and you will find the Offence Heart. Return to the area where you fought the tanks. As you walk farther down the street, you will be attacked by the infested chopper. Don't bother fighting it, just jump through the hole at your right. Walk up the stairs in front of you in this new room, and you will again be attacked by the chopper. You have to jump to the top of the building, before the flames below you catch up to you and kill you. The best way to do this is to just equip the Aerial Heart and fly to the top. Once you are there, go through the doorway to the roof. You now have to jump to the next roof while avoiding the chopper's fire. On the next roof, use the ledges to jump up to the top, and then continue to the next roof. Here you'll need to use the snake shaped ledges on the corner of the building to jump to the top. At the top of the building, you must do battle with the infested chopper. After it dies, the mission will end.

Mission 6- This mission is just one giant boss battle with Nefasturris. See the Boss section for tips.

Mission 7- You start in a fairly cubed shape room, and your goal is to get to the top of the far wall. Once here, jump on top of the pipe, and slide into the next area. You'll now be outside, and your goal is to get to the end of the walkway. Explore this area, and you will find a group of boilers; behind them is a yellow orb. Go to the door, and enter the next area. You'll now be on a spiral staircase, and you need to get to the bottom while avoiding enemies. At the bottom, you should enter the cylindrical room and use your Aerial Heart to fly up to the top. Here You'll find the Flame Heart. Go back down to the bottom, and enter the door with the green lights on it. Be careful not to fall into the pit in this room, but do jump onto the ledge in the pit and go through the door. Here you will find the Vendetta sword. Exit this room and jump to the other side of the room. Jump up to the ledge, and enter the door here. Use the Aerial heart to fly up to some red orbs in this room. Ride the elevator to the bottom, and you will find yourself in front of a small train. Once you enter the train, you will be attacked bym some Agnofinis. Be sure to destroy all of the crates while you are fighting to receive some red orbs. Go up the elevator at the end of the hall, and go through the door to end the level.

Mission 8- This mission is just a boss fight with Furiataurus. Make sure to destroy all of the crates in this room to get all of the red orbs.

Mission 9- After you exit this main room, you will have 12 minutes to escape the building before it explodes. Jump back down the elevator shaft, and fight some of the enemies here if you want to. Don't spend too much time fighting, or you might not make it out. Follow the railway path down the right fork, and go through the door on the right wall. You will now be in the room where you got the Vendetta and if you didn't get it earlier, you can pick it up now. Exit the room and jump out of the pit. From here, jump up the ledges and exit out of the door. Run back up out of the spiral staircase, and avoid the exploding enemies. When you exit the room, you will be back outside, and you will need to light up 3 orbs before the door will unlock. When you go through the door, you will be in the room that you started the mission in. Jump back up to the door near the pipe and enter it. Go through the door in this room. The fan in this room will make it hard to run, but you need to enter the plane in the middle of the room. Smash the crate in the right corner to find the rocket launcher. Exit the plane, and go through the hole that the plane made in the fan to end the mission.

Mission 10- You'll start this level in a large courtyard. Explore the area to find orbs, and kill the Pyromancers to build up your DT gauge. Now equip the quick heart, and go to the right side of the courtyard. Here you should find a statue. Hit the statue, DT, and run to the other side of the courtyard. Hit the statue here, if you made it on time, the gate at the end of the courtyard should open up. Go through the gate, and light up the statue inside. A staircase should open up, but before you can reach it, you will be sucked into the ground. Here you must kill the 2 Savage Golems in the room. After that, You will begin a boss battle with Nochpteran. After the fight, collect any orbs still lying around, and head back to the surface. Go down the stairs to end the mission.

Mission 11- Follow the path until you reach a door about halfway down. Go through the door to start another secret mission. After that, head down the path, fighting enemies, until you can safely cross into the next room. Drop down into the pit on your left and smash the vases here for some red orbs. In the next room, you can either fight the enemies, or just ignore them and continue on down the path. in the next room, you have to jump up on the middle pillar and smash the blue statue. The room will rotate, and you will have to use the pillars to jump up into the new opening. Follow this corridor until you reach a downward sloped one. Equip the Quick Heart and begin walking down the corridor. A giant red eye will fall down behind you, now quickly DT and run to the end of the path. If the eye hits you, then you will be teleported to another room, and forced to fight 2 Savage Golems. You'll then be teleported back to the corridor, and you'll have to try again. When you make it to the end, you will fall into a room with a giant crushing device in the middle. In this room you should be able to jump up or fly up until you find another blue orb. While the crusher is going up, you should run to the end of the room and start smashing the door. Run back before it comes back down, and then try again. Follow the new corridor, and you'll end up in a room with red pillars. Use the walls to jump up to the second floor. And use the floating red and blue floors to jump across the room. Or you could just use the Aerial Heart. Next to one of the blue floors is a hallway, at the end of it you will find the sub machineguns. Go across the room and enter another hallway. Midway through this hallway you will find 3 pots. The object of this puzzle is to have all 3 of them smashed at the same time. If you are too slow however, the pots will reappear. The best way to do this is to smash one pot until it is almost destroyed, then move on to the next pot. Once one pot is destroyed, quickly DT (with the Quick Heart equipped) and smash the other 2. Now run to the end of the hall to acquire the Healing Heart. Jump down into the pit to start a boss fight with Bolverk. After the fight, go through the door to end the mission.

Mission 12. When you take control, you will be surrounded by an energy force field. You must jump up and smash all of the diamonds to destroy the force field. The only problem is that they are constantly moving and so is the force field. Don't bother trying to kill the Sargasso, they will just keep coming back. After you smash the last diamond, drop down through the hole in the floor and smash all of the pots in this room. Go through the door to start a boss fight with Plutonian. After the fight, go through the doorway to end the mission.

Mission 13- This is basically just a boss fight with Arius.

Mission 14- Dante will start facing the screen, turn him around and run towards the statue of time. Keep going until you come to a corner. If you check to your left, you can find the Missile Launcher if you missed it earlier. Turn the corner, and you should be attacked by some blood goats. Kill the blood goats and jump up on the rooftops. Run back the direction you came until you reach a roof with a single red orb on it. Now use the Aerial Heart to fly up and smash the statue above this roof. Follow the path now until you reach the spot where you first fought the Msira. jump up through the doorway and kill all of the enemies in here. Now run to the back left corner to find the second statue. Exit this area and continue to follow the path until it splits into two directions again. Keep going towards the screen, and at the end of the path you will find some Savage Golems and the third statue. When you're done, retrace your steps and follow the other path. Stay close to the left wall, and you should find a pathway. Follow this, and jump up on the ledges to receive another blue orb. Kill the pyromancers in this room, and use the Aerial Heart to fly up and smash the statue. If you run out of juice, just keep double jumping and slashing down on the statue. Enter the door and slash the eyeball in the middle of the statue to start the boss fight with Phantom. When he is dead, the mission will end.

Mission 15- Before you hit the eye again, examine the spider web like mound on the right side of the room. The object of this is to knock 3 enemies into it using high time or stinger. Now, hit the eyeball. Several enemies will attack you, and you must kill them all before you can enter the underworld. You have three minutes to do this, and if you run out of time, you will have to try again. Try to fight over by the mound, if you do manage to knock 3 into it, you will receive the Chrono Heart. Use the DT whenever possible to kill off many enemies at one time. When you kill enough enemies, you will be able to jump into the center of the starfish and end the mission.

Mission 16- Before you can take the elevator in front of you, you must kill all of the enemies in this room. On the elevator, you will be attacked by several enemies. This is a good place to get a stylish rating because of the close quarters. At the bottom, smash all of the pots to obtain red orbs, and go through the door at the end of the path. Follow the path until you reach another door and go through it. Here you will have to reach the end of the room without touching any of the red eyeballs. Two will come at you from the middle, then 2 on the side, and then 2 in the middle again. The best thing to do is to hide in the small alcove in the corner until the ones on the side roll by, and then go forward again. Now there will be 4 coming at you from all different directions. The best thing to do is to double jump over them. If any of them touch you, you will have to fight 2 Savage Golems, and then try again. You should now be at the back wall. Go through the door here to find another secret room, then jump up to the balcony. Take the Sacrilege, and explore the balcony to find a blue orb piece. Put the Sacrilege in the door and head back out. Ignore the Pyromancers and follow the path until it splits in 2. Take the one in front of Dante, and go through the door here. You will now have to fight Bolverk again. When he is dead, take the sacrilege and exit the room. Follow the hallway, and there should be a pathway to your right lined with red orbs. Go through the door, and kill all of the enemies to receive the sacrilege. Exit the way you came in, and head back down the hall. Turn to Dante's left, back toward where you got the second Sacrilege. Turn left now and go through the new door. Smash the orb, and kill all of the Blood Goats to receive the Frost Heart. Go back to the room where you found the third Sacrilege, and take the elevator down. This time you will be attacked by harder enemies in the elevator, but they shouldn't give you too much trouble. Go through the door, and begin the boss fight with Trismagia. After that the mission will end.

Mission 17- Go through the door in front of you to start the boss fight with Arius. After he is dead, the mission will end.

Mission 18- Fight Argosax the Chaos and Despair Embodied to win the game.