Mission 2- Go up the stairs in this first room and attack the sphere. You'll be attacked by 2 goatlings now, one on the ground and one in the air. Be sure to take down the one in the air first so that he doesn't give you problems while you are fighting the other one. When they are dead, you will receive the Aerial Heart. Use this to fly up and out of the room. Go up the stairs in this room and jump up on the platform. Jump up again and destroy the platform to receive the Darts, also there should be a blue orb somewhere in the air here. Continue to jump up the platforms until you reach an orb generator. Destroy this, and jump up to the circular platform to exit the room. Fly up to the orb in this room, and begin to smash it.
You should then be able to fly up and out of the level that opens up. Go up the stairs, and fight your first boss, Tartarussian. Enter the small area at the front of the room to open the door and to receive a blue orb. Go up the stairs and collect the orbs around the platform. When you are done,jump off of the platform to end the mission.

Mission 3- Go down the street until you are attacked by a Goatling. Just keep dodging to avoid the energy coming up from the ground. Jump up and kill the Goatling, then go through the door on your left. The Klyamoors should be on the ground in here, after you get them, exit the room. Go through the large door with a red orb beside it. Go down the street, and use the platforms to jump up and receive a blue orb. Kill the enemies on the road, and attack the doorway at the end of the road. Go through it, and jump up the platforms on the cliffs until you find a blue orb. Go to the far end of the area, and enter the door here. Kill the enemies in this room, and search the large carving on the stairway to find another secret room. Go into the room at the top of the stairs, and collect the healing heart. Go back outside to the waterfront, and enter the large archway. Climb up the stairs and search the top to find another secret room. Go back downstairs and enter the large door. Fight Jokatguim, and exit through the door that opens to end the mission.

Mission 4- Jump into the tunnel to find a blue orb. Go down the tunnel and get the Offence Heart from the refuse in the wall to your right. Continue down the street, and fight Orrangguerra. When he is dead, enter the tunnel, and continue down the street. You will be attacked by an infested tank. Alternate between dodging and throwing knives until you make your way down the street and are able to attack it. When it is dead, the mission will end.

Mission 5- Head into the room and jump down into the middle. Jump up to the other side and go through the door over here. Jump to get the orb, and go through the door. Collect the orb on the plane, and enter through the back of it. Start smashing the boxes to receive the cranky bombs. Leave the plane and go through the door near the end of the room. Smash the orb here and leave the room. Go back to the room you started in and go through the garage like door. Here you will receive the Evil Heart, which slowly drains your health. Jump down into the main area and run to the back of the boiler tanks on the left side of the area to receive a blue orb. Go through the door at the end of the area. Smash the orb and run down the stairs. When you are attacked, hit the spiciers with a melee weapon to kill the whole group. Go all the way to the bottom and use the DT charger to restore your DT and your health. Enter the cylindrical room, and use the Aerial Heart to fly up to the top and receive the Flame Heart. Jump down and go through the door in the hall. Jump down into the pit here, and go through the door at the back of the room. Walk to the back and place the Evil Heart in the recess to receive the Electro Heart. Go out of the other door in here, and travel down the train tracks. Use the elevator to go to the top floor. Go through the doorway on the right to find another secret room. Go through the door at the end of the hall to end the mission.

Mission 6- Kill all of the enemies in the area that you start out in to begin the boss battle with Noctpteran. After the battle you will be transported to a new area. Get the blue orb in here, and use the Aerial Heart to fly to the top of the pillars. Fly to the ledge along the next wall, and search the hole here to find another secret room. Jump down into the water, and look for the Bow Gun under the ledge where you found the blue orb. Swim to the giant door to end the mission.

Mission 7- Keep swimming down the corridor that you start in, and search the small recess in the wall to reveal a blue orb. Swim up the hole in the ceiling, and go through the door into the next area. Grab the Aqua Heart, and jump up on the ledge above it. From here, jump to the next ledge and start smashing the vases in here for red orbs. Go through the doorway on the right to find another secret room. When you are done, go down the hallway to your right, and jump into the water. When you swim into the next room you should go through the hole that you see in the cut-scene. Kill all of the enemies in this room so that you can complete the puzzle in peace. The goal here is to light up all 6 of the different orbs at the same time. Use the Aqua Heart to do this. Jump up on the platforms that appear, and smash the orb at the top. Go back down into the previous room where you saw the cut scene, and swim to the door. Fight Tateobesu, and swim up into the hole to cause the mission to end.

Mission 8- Look in the small area right above where you start to find another secret room. Search the area to find a Gold Orb behind one of the pillars. Leave through the hole in the ceiling, and examine the large eye at the end of the room. The goal here is to knock three fireballs back at the eye using your swords. After the water level raises, look behind one of the statues to find a Blue Orb fragment. Swim through the hole in the room, and run down the hallway that you emerge in. Jump back into the water at the end of the hall and swim down into the next room. Look for a hole in the floor, and swim down it to find another blue orb. leave the hole and swim through the other hole in this room near the back. go through the door, and examine the glyph near the back. The object now is to break 8 of the spheres with your sword. Jump over the blocks for the fastest results. Jump up on the platforms that appear, and go through the door. Run until you find 3 orbs. The object of this is to break all 3 at the same time, and then run to the end of the room. The best way to do this is to hit one of the orbs until it is almost destroyed, then go on to the next one. When one is destroyed, DT and quickly destroy the other 2. Then, run to the end and grab the Quick Heart before the orbs can reform. Go through the door, and fight Plutonian. jump up on the pedestal, and go up to end the mission.

Mission 9- Fight Arius, that's basically the whole mission.

Mission 10- Run forward when you start and look for the first statue, it should be near a pillar with a red orb on it. You have to activate 4 of these in this mission, and this one will be the first. After you activate it, look for a door on the left side of the street, and you should find another secret room. Go back down the right fork in the road, and activate another orb near the arena where you first fought the Msira as Dante. After you activate it, jump into the arena, and search the back to find a blue orb. Keep going down the street, and look for another orb on the right to smash. When you're done, continue down the street until you get to the area where Dante jumps over the gap on his motorcycle. Here you will find the Zambaks. Run down the left side of the street until you find a passageway. Go down it, and look for the final orb up on a ledge to your right. Go through the large door on the right, and hit the eye in the middle of the giant starfish. This will activate the boss fight with Phantom, and when he is dead the mission will end.

Mission 11- Before you hit the eye again, examine the spider web like mound on the right side of the room. The object of this is to knock 3 enemies into it using high time or stinger. Now, hit the eyeball. Several enemies will attack you, and you must kill them all before you can enter the underworld. You have three minutes to do this, and if you run out of time, you will have to try again. Try to fight over by the mound, if you do manage to knock 3 into it, you will receive the Chrono Heart. Use the DT whenever possible to kill off many enemies at one time. When you kill enough enemies, you will be able to jump into the center of the starfish and end the mission. If you fail to do it in 3 minutes, you will have to try again, but the enemies will get easier. Use the Chrono Heart to make things easier.

Mission 12- Kill all of the Goatlings in the starting area, and leave. The elevator is a great place to get orbs because it is such a small area. As long as you keep dodging, you can get good style ratings. Run down the right way of the hall and smash one of the vases. Check the wall here to find another Secret Room. Run down to the other end of the hallway and go through the door. Continue down the hall, and go through the door at the end. Kill the enemies in here, and use the sacrilege that you receive on the door. Go back out and go through the new hallway until you reach the door. Go through the door. Here you will have to reach the end of the room without touching any of the red eyeballs. Two will come at you from the middle, then 2 on the side, and then 2 in the middle again. The best thing to do is to hide in the small alcove in the corner until the ones on the side roll by, and then go forward again. Now there will be 4 coming at you from all different directions. The best thing to do is to double jump over them. If any of them touch you, you will have to fight 2 Savage Golems, and then try again. You should now be at the back wall, jump up and get the sacrilege. Look for another blue orb at the end of the balcony. Place the sacrilege in the door and leave. Look for a trail of orbs on the right of the screen, go down the path and go through the door. Fight Trismagia and go through the door at the end of the room. Go up the elevator, and enter the room at the end of the area to end the mission.

Mission 13- Fight Possessed Arius and Arius Argosax to finish the game.